Document Type
Article
Publication Date
10-2015
Department
Pharmacy Faculty
Abstract
Background: In 2004, the Infectious Diseases Society of America (IDSA) published monitoring guidelines for outpatient parenteral antimicrobial therapy (OPAT), but no assessment of their utilization has been reported. We evaluated adherence to these recommendations by physicians at infusion centers and then piloted a program of supervision of monitoring by pharmacists.
Methods: Phase I: We performed a retrospective case-control study of patients who received OPAT over one year at two hospital infusion centers. Controls were patients treated by an infectious diseases (ID) physician, and cases were those without an ID physician. Patients were excluded if they received fewer than 3 days of OPAT. Clinical pharmacy monitoring services were then implemented for patients on OPAT prescribed by non-ID physicians at one hospital’s infusion unit. Two outcomes were measured: adherence to guidelines on monitoring, and attainment of goal vancomycin and aminoglycoside serum concentrations when appropriate. The results for non-ID physicians were compared to both ID physicians and subsequently a pharmacist.
Results: Ninety nine patients were included in the retrospective study. Compared with patients who had ID physician supervision, the non-ID physicians who prescribed OPAT for 39 patients had lower adherence to monitoring recommendations (35.9% vs.68.3%, p=0.003). No difference could be detected in achievement of goal vancomycin and aminoglycoside serum concentrations for the 14 cases and 19 controls requiring therapeutic drug monitoring (57.1% vs. 68.4% respectively, p=0.765). Seven patients were enrolled in the study after pharmacy monitoring was implemented. Adherence to monitoring recommendations for these patients was significantly improved compared to the prior patients that lacked ID physician supervision (35.9% vs. 100%, p=0.0065).
Recommended Citation
Shah, Punit J.; Bergman, Scott; Graham, Donald; and Glenn, Stephanie, "Monitoring of outpatient parenteral antimicrobial therapy (OPAT) and implementation of clinical pharmacy services at a community hospital infusion unit" (2015). SIUE Faculty Research, Scholarship, and Creative Activity. 32.
https://spark.siue.edu/siue_fac/32
Comments
This paper is the Accepted Manuscript version of an article published by SAGE in Journal of Pharmacy Practice, available online at http://dx.doi.org/10.1177/0897190014544786.