Prophylactic Tranexamic Acid Administration to Prevent Postpartum Hemorrhage After Cesarean Delivery in Patients at High Risk of Severe Postpartum Bleeding

Author

Alexandra WhiteFollow
Stephanie Lafikes, SIUEFollow

Date of Award

Spring 5-5-2023

Document Type

DNP Project

Project Team Faculty Member

Dr. Mary Zerlan

Project Team Faculty Member

Dr. Whitney Heischmidt

Project Team Faculty Member

Dr. Rebecca Collier

Keywords

postpartum hemorrhage, tranexamic acid, TXA, cesarean section, antifibrinolytic

Abstract

Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. Cases of PPH are increasing in the United States, and despite current treatment recommendations, mortality remains high. This project included a review of the research on the use of prophylactic tranexamic acid (TXA) administration to prevent or reduce blood loss after cesarean delivery. Statistics regarding the impact of PPH and the pharmacology of TXA were reviewed in detail. Evidence shows that TXA is safe for parturients and nursing infants. Further evidence shows prophylactic TXA administration is associated with a modest reduction in blood loss, the need for blood transfusion, and post-delivery drop in hemoglobin and hematocrit after cesarean delivery. This information was shared with obstetric and anesthesia staff at a level III perinatal center in central Illinois as an informative PowerPoint presentation. Thirteen pre and post-test surveys were collected from staff which showed an improvement in knowledge regarding the use of TXA as a prophylactic measure in the management of PPH. The goal of this project was to ensure that the individuals providing direct patient care are aware of up-to-date research findings on this therapy which may clinically benefit their patients.

Recommended Citation

White, Alexandra and Lafikes, Stephanie, "Prophylactic Tranexamic Acid Administration to Prevent Postpartum Hemorrhage After Cesarean Delivery in Patients at High Risk of Severe Postpartum Bleeding" (2023). Doctor of Nursing Practice Projects. 254.
https://spark.siue.edu/dnpprojects/254

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