Date of Award

Spring 5-5-2023

Document Type

DNP Project

Project Team Faculty Member

Dr. Mary Zerlan

Project Team Faculty Member

Dr. Whitney Heischmidt

Project Team Faculty Member

Dr. Rebecca Collier


postpartum hemorrhage, tranexamic acid, TXA, cesarean section, antifibrinolytic


Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide. Cases of PPH are increasing in the United States, and despite current treatment recommendations, mortality remains high. This project included a review of the research on the use of prophylactic tranexamic acid (TXA) administration to prevent or reduce blood loss after cesarean delivery. Statistics regarding the impact of PPH and the pharmacology of TXA were reviewed in detail. Evidence shows that TXA is safe for parturients and nursing infants. Further evidence shows prophylactic TXA administration is associated with a modest reduction in blood loss, the need for blood transfusion, and post-delivery drop in hemoglobin and hematocrit after cesarean delivery. This information was shared with obstetric and anesthesia staff at a level III perinatal center in central Illinois as an informative PowerPoint presentation. Thirteen pre and post-test surveys were collected from staff which showed an improvement in knowledge regarding the use of TXA as a prophylactic measure in the management of PPH. The goal of this project was to ensure that the individuals providing direct patient care are aware of up-to-date research findings on this therapy which may clinically benefit their patients.

Download Full Text Above

TXA PPH Lit Review_Lafikes and White.docx (37 kB)
Literature Review

Conceptual Framework_Lafikes and White.docx (15 kB)
Conceptual Framework

Methodology_Lafikes and White.docx (16 kB)
Project Methods

evaluation and outcomes_Lafikes and White.docx (21 kB)
Evaluation Process/Instruments

references_Lafikes and White.docx (18 kB)
Final Reference List



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