Date of Award

Spring 5-6-2022

Document Type

DNP Project

Project Team Faculty Member

Whitney Heischmidt

Project Team Faculty Member

Rebecca Collier

Project Team Faculty Member

Jenna Winters


LAST, local anesthetic systemic toxicity, CBL, computer-based learning, local anesthetic, intralipid, lipid emulsion


Local anesthetic systemic toxicity (LAST) is the result of rapid absorption of local anesthetics (LAs) into the systemic circulation resulting in toxic plasma levels of the drugs. With the advent of ultrasound-guided regional anesthesia and improvements in injection techniques, the incidence of LAST has decreased significantly over the years. Even though LAST is rare, it is a potential, life-threatening complication associated with any administration of LAs. Providers and staff members taking care of patients receiving LAs should be astutely aware of potential complications so that LAST signs and symptoms can be recognized, and treatments can be implemented as swiftly as possible. The project aimed to develop and implement a computer-based learning module about LAST and its management. The module was disseminated via HealthStream, a web-based learning management system, to Registered Nurses, Certified Registered Nurse Anesthetists, and Physician Anesthesiologist at a tertiary care center in central Illinois. The project was based on a non-experimental pretest-posttest single group design to assess participants’ knowledge before and after implementation of the CBL module. The module was completed by 116 participants, and results were evaluated. The average pretest score was 55%; the average of the posttest was 87% with an average of 1.3 attempts, which was 32% higher compared to the pretest. This project identified knowledge deficits regarding LAST and emphasized the necessity for further education on LAST. Thus, this project supported the use of a CBL module as a means to educate providers and staff members and will help promote awareness, vigilance, and readiness among healthcare providers and has the potential to keep the patient safe should this life-threatening complication occur.

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